Dr.Ian MacKenzie, B.Sc. (Hons), PhD.

Peer-reviewed publications

1. 'Safer Medicines ' (2005)
Academy of Medical Sciences Forum Report
IM was Invited Member of Safety Pharmacology Expert Working Group
(chaired by Dr Rob Wallis and Prof Tim Hammond)

2. 'Designing a comprehensive cardiovascular safety testing regimen.' (2005)
In Covance Evolutions, Vol. 10, Number 1.
I MacKenzie and D Sarazan

3. 'Safety Pharmacology for the non-clinical assessment of medicinal products ' (2002).
Drug Discov. Today 7, 232-234
I MacKenzie

4. 'Safety Pharmacology Requirements for the development of human cardiac/cardiovascular pharmaceuticals' (2002)
Drug Devel. Research 55, 73-78
I MacKenzie

5. 'Relationships between preclinical cardiac electrophysiology, clinical QT prolongation and torsade de pointes for a broad range of drugs : evidence for a provisional safety margin in drug development' (2003)
Cardiovascular Res. 58, 32-45 . Review
Redfern WS , Carlsson L , Davis AS, Lynch WG, MacKenzie I, Palethorpe S, Siegl PK, Strang I , Sullivan AT, Wallis R, Camm AJ, Hammond TG

6. 'Methods of collecting and evaluating non-clinical cardiac electrophysiology data in the pharmaceutical industry :results of an international survey' (2001)
Cardiovascular Res. 49, 741-750
Hammond TG , Carlsson L, Davis AS , Lynch WG, MacKenzie I, Redfern WS, Sullivan AT, Camm AJ

7. 'A K(ATP) cannel opener inhibited myocardial reperfusion action potential shortening and arrhythmias' (2001)
Eur. J. Pharmacol. 419, 73-83
Workman AJ, MacKenzie I, Northover, BJ

8. 'Do KATP channels open as a prominent and early feature during ischaemia in the Langendorff-perfused rat heart ?' (2000)
Basic Res. Cardiol. 3, 250-260
Workman AJ, MacKenzie I, Northover, BJ

9.'Differential Class III and glibenclamide effects on action potential duration in guinea-pig papillary muscle during normoxia and hypoxia /ischaemia' (1993)
Br. J. Pharmacol. 110, 531-538
MacKenzie I, Saville VL, Waterfall JF

10.'Effects of pinaverium on voltage-activated calcium channel currents of single smooth muscle cells isolated from the longitudinal muscle of the rabbit jejunum' (1990)
Beech DJ, MacKenzie I, Bolton TB, Christen MO
Br. J. Pharmacol. 99, 374-378

11. ' Calcium currents in single isolated smooth muscle cells from the rabbit ear artery in normal-calcium and high-barium solutions' (1988)
Aaronson PI, Bolton TB, Lang RJ, MacKenzie I
J. Physiol. 405, 57-75

12. 'Calcium channels in smooth muscle cells' ((1988)
Bolton TB, MacKenzie I , Aaronson PI, Lim SP
Biochem. Soc . Trans. 16, 492-493.

13.'Voltage-dependent calcium channels in smooth muscle cells' (1988)
J. Cardiovasc. Pharmacol. 12 Suppl. 6, S3-S7
Bolton TB, MacKenzie I , Aaronson PI

14. 'Voltage -dependent calcium channel in intestinal and vascular smooth muscle cells' (1988)
Ann. N.Y Acad. Sci.522, 32-42
Bolton TB, Aaronson PI, MacKenzie I

15. Regulation of voltage-dependent excitatory responses to alpha, beta, methylene ATP, ATP and non-adrenergic nerve stimulation by dihydropyridines in the guinea-pig vas deferens' (1988)
Neurosci. 27, 317-332
MacKenzie I, Manzini S, Burnstock G

16. 'Comparative study of the actions of AP5A and alpha-beta-methylene ATP on nonadrenergic, noncholinergic neurogenic excitation in the guina-pg vas deferens' (1988)
Br. J. Pharmacol. 94, 699-706
MacKenzie I, Kirkpatrick KA, Manzini S, Burnstock G

17. 'Neuropeptide action on the guinea-pig bladder; comparison with the effects of field stimulation and ATP ' (1984)
Eur. J. Pharmacol. 105, 85-94
MacKenzie I, Burnstock G

18. 'Studies on the stereoselectivity of the P2- purinoceptor' (1983)
Br . J. Pharmacol. 79, 907-913.
Burnstock G, Cusack NJ, Hills JM, MacKenzie I , Meghji P

19. 'The effects of purified botulinum type A on cholinergic, adrenergic, and non-adrenergic,atropine-resistant autonomic neuromuscular transmission.' (1982)
Neurosci. 7, 997-1006
MacKenzie I, Burnstock G and Dolly JO

20.'Evidence against vasoactive intestinal polypeptide being the non-adrenergic, non-cholinergic inhibitory transmitter released from nerves supplying the smooth muscle of the guinea-pig taenia coli.' (1980)
Eur. J.Pharmacol. 67, 255-264
MacKenzie I, Burnstock

PhD Thesis in Pharmacology Board of Studies , awarded 1982 by University College, University of London. 'Polypeptides and ATP : putative autonomic neuromuscular transmitters'
Supervisor Prof G Burnstock, FRS

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